Dynamic42 opens new possibilities for tissue-based drug research at ELRIG 2026

Source: SelectScience (October 14, 2026). AI-generated summary by biochip.com, published October 17, 2026. Not independently reviewed.

Dynamic42 has introduced the DynamicOrgan Load&Seal Kit, an open-top, two-channel biochip designed to place tissue slices, solid drug depots, and biomaterials directly into a perfused culture chamber. The Jena, Germany-based organ-on-chip company says the format preserves more of a tissue sample's native structure while letting researchers control fluid flow around it. That combination could give drug researchers a more realistic way to study how tissues respond to compounds before moving into later-stage testing. Dynamic42 will display the kit at booth C04 during ELRIG Drug Discovery 2026 in London on October 14 and 15.

Opening a chip for intact tissue

Organ-on-chip systems are small devices that recreate selected features of living tissues under controlled laboratory conditions. They can be thought of as miniature, plumbed tissue environments: cells or samples sit in chambers while fluid supplies nutrients and removes waste.

Traditional closed microfluidic chips can make it difficult to insert intact tissue pieces because their fluid ports are narrow. The Load&Seal design addresses that practical barrier by leaving the top channel accessible during setup. Researchers place a sample in the chamber, close it with supplied bonding foil, and then connect the device to a perfusion pump.

Two channels, independently controlled flow

The biochip contains two channels separated by a porous membrane, a thin barrier with microscopic openings that permits selected material exchange between the channels. Researchers can run the channels at different flow rates, allowing the conditions on each side of the membrane to be adjusted for a particular experiment.

The kit is designed without PDMS, or polydimethylsiloxane, a silicone material widely used in microfluidic devices. Dynamic42 says the PDMS-free construction helps reduce drug adsorption, meaning less of a test compound may stick to the device material instead of remaining available to interact with the tissue.

From a customer request to a kit

Dynamic42 developed the format after a customer asked to place a solid drug depot inside one of its biochips and examine it under flow. The team adapted its existing two-channel design so the material could be placed directly into the device, then made the resulting open-top format available as a kit for other laboratories.

“Our customers bring us specific research questions and practical challenges,” said Anne-Katrin Dietsch, Product Manager for Biochips at Dynamic42. “Load&Seal grew out of one such collaboration and now extends the experimental options available to other users of our platform.”

Tissue models under perfusion

The broader DynamicOrgan platform supports perfused models of the intestine, lung, liver, and other tissues, including models that incorporate immune cells. Perfusion means continuously moving culture fluid through the system rather than leaving a sample in a static pool of liquid.

For tissue slices and explants, pieces of tissue maintained outside the body, flow can continuously deliver nutrients and oxygen while carrying away metabolic waste. Dynamic42 says this can extend the culture period and experimental timeframe while retaining tissue architecture, including interactions among different cell types and the surrounding extracellular matrix, the supporting material around cells.

Why This Matters

Drug responses depend not only on individual cells but also on how cells interact with neighboring cells, the local tissue structure, and chemical signals around them. By combining intact tissue with controlled flow, the Load&Seal system is intended to let researchers test those responses in a more defined experimental environment than a conventional static culture.

The kit is available in several pack sizes and membrane pore sizes. Laboratories that need the accompanying fluid-handling hardware can purchase the DynamicOrgan Load&Seal System, which includes a pump. Dynamic42 is developing explant-culture applications for cancer and other biomedical research areas, where application-specific validation will determine whether these models can complement or replace selected animal experiments.

Topics: Biochip · Drug development & safety

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